Key Points

  • Benadryl is an effective antihistamine. However, it can produce some side effects and may be passed to a baby through breast milk.
  • First-generation antihistamines like Benadryl may cause drowsiness in breastfed infants.
  • Second-generation antihistamines reduce risks. However, they should not be taken in large doses or long-term.
  • There have been reports of minor side effects among infants breastfed while mothers take antihistamines. However, there are still gaps in the research. Many experts agree more evidence is needed.
  • Alternative options are available. These include inhaled corticosteroids.
  • If you plan to take any new medication while breastfeeding, speak with your healthcare team.
For some people, allergies are something they have learned to deal with. Airborne allergies, like those associated with hay fever, often have people reaching for over-the-counter (OTC) medications. Benadryl is one option that has been around for decades. This antihistamine, clinically referred to as diphenhydramine, is also commonly taken by those suffering from the common cold and is sometimes recommended for those who experience motion sickness.  While Benadryl is relatively easy for adults to access, there are concerns, especially when taking too much. Based on these warnings, Benadryl is not ideal while breastfeeding, as it can be passed on to the feeding infant. [1] What alternatives exist? This guide covers everything you need to know concerning Benadryl and breastfeeding, focusing on your baby’s health. 

Benadryl: What Is It and How Does It Work?

Benadryl is a first-generation antihistamine. This class of drugs are older medications that work by blocking histamine receptors. As a result, users can reduce symptoms like itching, sneezing, and a runny nose. Other antihistamines in this category include Tylenol Cold and Cough and Nytol.  Since these OTC medications are easy to obtain and relatively effective, they are commonly taken. However, they can cause symptoms like drowsiness (medications like Benadryl readily cross the blood-brain barrier, causing this side effect). Some also experience dizziness and low blood pressure. [1] These effects are why many seek second-generation antihistamines like fexofenadine (Allegra), as they are less likely to cause drowsiness and sedation. [2] 

Antihistamines and Breastfeeding: What Are the Risks?

woman cradling young baby in her arms When taking Benadryl and other antihistamines, like cetirizine, there may be risks to breastfed infants. Unfortunately, medication use is one reason for early weaning, as breastfeeding rates drop to 13%–39% at six months postpartum. [3] When considering allergens, it’s estimated that up to 20%-30% of women have allergic conditions that require treatment during pregnancy and breastfeeding. [3] Reviews have reported few adverse drug reactions among newborns and infants exposed to antihistamines via breast milk. A review of 53 reports, including breastfed infants exposed to all types of medications, found that 75% of reactions appear in those under two months of age — primarily reacting to drugs that act on the central nervous system. [3] None of the reports involved antihistamines.  Other reviews have documented a potential link, with reactions being categorized as minor. For example, increased drowsiness and irritability, which did not require medical attention. However, researchers agree that there is a knowledge gap and that data on the true risks is insufficient. [3] While some feel the risk is low, researchers have listed “breastfeeding mothers” and “premature infants” as known Benadryl contraindications. [1] If you’re someone who would rather not risk any potential side effects, regardless of severity, you can explore alternative options.  Please note: When planning to take any medication while breastfeeding, you should consult your healthcare team to discuss the risks.

Alternatives to Benadryl? Options for Breastfeeding Mothers

As discussed earlier, Benadryl is a first-generation antihistamine that can cause drowsiness in users. So, if you need an antihistamine, explore non-sedating options with your care team. There are several options on the market, most of which come in tablet form. However, these are not recommended long-term. [4] A 2025 review on cetirizine, a second-generation antihistamine, concluded that small occasional doses are acceptable during breastfeeding. [5] However, high doses or prolonged use could cause drowsiness in infants. There are also concerns surrounding decreased milk production.  Two other options are nasal rinses or sprays and eye drops. Whether these are effective will depend on the cause of your symptoms. If you are seeking treatment for hay fever, allergies, or sinusitis, talk to your doctor about inhaled corticosteroids. A 2024 review reported the following hypothesis: inhaled corticosteroids absorbed into the bloodstream of a mother and excreted into breast milk are probably too small to affect the breastfed infant. [6] Experts consider this option acceptable to use during breastfeeding. 

Ensure a Safe and Healthy Future for You and Your Baby

Once you have a baby, there are many considerations — especially when what you consume can decrease your milk supply. If you have symptoms that require pharmaceutical intervention, discuss what options are available to weigh the proposed benefits vs. the potential risks.  If you are a breastfeeding mother struggling with any increased consumption of prescribed medications, illegal drugs, or alcohol, it is crucial that you seek assistance as soon as possible. Postpartum depression is another area to address as soon as possible. If you have concerns about your mental health or are wondering how antidepressants may influence your milk supply, speak with a clinical professional.  Having the support of a treatment facility like Southeast Addiction Center TN can make all the difference. If you or someone you love need to speak to someone about their current substance use, please contact our team today!